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Mutation Report for: Y124Q_mouse-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|Y124Q
Torpedo number|121
Kinetic parameters|Acetylthiocholine_Y124Q_mouse-ACHE,

    Title: Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP
    Kovarik Z, Ciban N, Radic Z, Simeon-Rudolf V, Taylor P
    Ref: Biochemical & Biophysical Research Communications, 342:973, 2006 : PubMed


    Title: Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases
    Saxena A, Fedorko JM, Vinayaka CR, Medhekar R, Radic Z, Taylor P, Lockridge O, Doctor BP
    Ref: European Journal of Biochemistry, 270:4447, 2003 : PubMed


    Title: Amino acid residues involved in the interaction of acetylcholinesterase and butyrylcholinesterase with the carbamates Ro 02-0683 and bambuterol, and with terbutaline
    Kovarik Z, Radic Z, Grgas B, Skrinjaric-Spoljar M, Reiner E, Simeon-Rudolf V
    Ref: Biochimica & Biophysica Acta, 1433:261, 1999 : PubMed


    Title: Reversible inhibition of acetylcholinesterase and butyrylcholinesterase by 4,4'-bipyridine and by a coumarin derivative
    Simeon-Rudolf V, Kovarik Z, Radic Z, Reiner E
    Ref: Chemico-Biological Interactions, 119-120:119, 1999 : PubMed


    Title: Site of fasciculin interaction with acetylcholinesterase
    Radic Z, Duran R, Vellom DC, Li Y, Cervenansky C, Taylor P
    Ref: Journal of Biological Chemistry, 269:11233, 1994 : PubMed


    Title: Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors
    Radic Z, Pickering NA, Vellom DC, Camp S, Taylor P
    Ref: Biochemistry, 32:12074, 1993 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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