Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : OP-resistance increased resistance to nerve agent retained robust intrinsic catalytic efficiency Dwyer_2014_Biochemistry_53_4476
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : OP-resistance
Torpedo_number : 334
Kinetic Parameter : No kinetic parameter
News : JUNE-11-2014
Comment : p.Y332S Tyr332Ser (p.Y360S Tyr360Ser in primary sequence with 28 amino-acids signal peptide) OP-resistance\;increased resistance to nerve agent retained robust intrinsic catalytic efficiency
| Title : Novel human butyrylcholinesterase variants: toward organophosphonate detoxication - Dwyer_2014_Biochemistry_53_4476 |
| Author(s) : Dwyer M , Javor S , Ryan DA , Smith EM , Wang B , Zhang J , Cashman JR |
| Ref : Biochemistry , 53 :4476 , 2014 |
| Abstract : Dwyer_2014_Biochemistry_53_4476 |
| ESTHER : Dwyer_2014_Biochemistry_53_4476 |
| PubMedSearch : Dwyer_2014_Biochemistry_53_4476 |
| PubMedID: 24902043 |