Hadroug_2024_Nat.Prod.Res__1

Reference

Title : Assessing Algerian Ilex aquifolium L.'s phenolic compounds, antioxidant and enzyme inhibitory properties to find a new natural remedy for Alzheimer's, diabetes and skin diseases - Hadroug_2024_Nat.Prod.Res__1
Author(s) : Hadroug A , Zengin G , Belhattab R , Cakmak YS , Rebbas K
Ref : Nat Prod Res , :1 , 2024
Abstract :

This research explored the impact of methanolic extracts from the fruits and leaves of Ilex aquifolium L., a rare Algerian species, on several enzymes, focusing on tyrosinase, alpha-amylase, alpha-glucosidase, and cholinesterases, as well as their antioxidant potential in vitro assays, including phosphomolybdenum, DPPH, ABTS, CUPRAC, FRAP, and MCA. HPLC-DAD analysis identified chlorogenic acid, rosmarinic acid, hesperidin, and quercetin as predominant phenolic components. Both extracts exhibited notable antioxidant properties, up to 250.08 mg TE/g for fruits and 237.08 mg TE/g for leaf extracts. Enzyme inhibitory assays demonstrated significant inhibition against AChE and BChE with maximum activities of 2.34 mg GALAE/g in leaves and 4.32 mg GALAE/g in fruits. Additionally, considerable tyrosinase inhibition was observed in leaves at 39.69 mg KAE/g. These findings highlight I. aquifolium L. as a valuable source for investigating natural antioxidants and enzyme inhibitors, particularly for possible cosmetics and food additives applications.

PubMedSearch : Hadroug_2024_Nat.Prod.Res__1
PubMedID: 39487751

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Citations formats

Hadroug A, Zengin G, Belhattab R, Cakmak YS, Rebbas K (2024)
Assessing Algerian Ilex aquifolium L.'s phenolic compounds, antioxidant and enzyme inhibitory properties to find a new natural remedy for Alzheimer's, diabetes and skin diseases
Nat Prod Res :1

Hadroug A, Zengin G, Belhattab R, Cakmak YS, Rebbas K (2024)
Nat Prod Res :1