Jin_2024_J.Alzheimers.Dis__

BACKGROUND: Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is a biomarker for the early diagnosis of Alzheimer's disease (AD). It remains unclear whether hepatorenal function affects the urinary AD7c-NTP level. OBJECTIVE: To evaluate the effects of hepatorenal function on urinary AD7c-NTP level. METHODS: We enrolled 453 participants aged 60-100 years. An automated chemistry analyzer was used to determine the indicators of serum hepatorenal function. Enzyme-linked immunosorbent assay was used to measure the urinary AD7c-NTP level. RESULTS: Spearman's correlation analysis showed a negative correlation between urinary AD7c-NTP levels and indicators of hepatorenal function, including albumin (r=-0.181, p<0.001), albumin/globulin ratio (r=-0.224, p<0.001), cholinesterase (r=-0.094, p=0.046), total carbon dioxide (r=-0.102, p=0.030), and glomerular filtration rate (r=-0.260, p<0.001), as well as a positive correlation with globulin (r=0.141, p=0.003), aspartate transaminase (r=0.186, p<0.001), blood urine nitrogen (r=0.210, p<0.001), creatinine (r=0.202, p<0.001), uric acid (r=0.229, p<0.001), and cystatin C (r=0.265, p<0.001). The least absolute shrinkage and selection operator (LASSO) regression analysis and multiple linear regression model analyses showed that the statistically significant hepatorenal indicators for predicting AD7c-NTP were A/G (p=0.007), AST (p=0.002), BUN (p=0.019), and UA (p=0.003). CONCLUSIONS: The effects of hepatorenal indicators should be considered when using urinary AD7c-NTP levels in clinical settings.