Paper Report for: Agbenyega_1995_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_111_397
Reference
Title: Effect of the beta 2-adrenergic agonist clenbuterol on the growth of fast- and slow-twitch skeletal muscle of the dystrophic (C57BL6J dy2J/dy2J) mouse Agbenyega ET, Morton RH, Hatton PA, Wareham AC Ref: Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology, 111:397, 1995 : PubMed
Clenbuterol (4mg/kg in diet for 21 days) had no statistically significant effect on whole body growth. It did cause a significant increase (18.2%) in wet weight of the fast twitch muscle extensor digitorum longus (EDL) and a corresponding 14.9% increase in total muscle protein. In transverse sections through dystrophic muscle fibre sizes were more variable than in normal muscle. Clenbuterol treatment resulted in a reduction in the proportion of small diameter fibres, and therefore an increase in mean fibre diameter, in dystrophic EDL. Clenbuterol had no significant effect upon the slow twitch muscle soleus.
        
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Agbenyega ET, Morton RH, Hatton PA, Wareham AC (1995) Effect of the beta 2-adrenergic agonist clenbuterol on the growth of fast- and slow-twitch skeletal muscle of the dystrophic (C57BL6J dy2J/dy2J) mouse Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology111: 397-403
Agbenyega ET, Morton RH, Hatton PA, Wareham AC (1995) Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology111: 397-403