Paper Report for: Ahmad_2008_J.Enzyme.Inhib.Med.Chem_23_313
Reference
Title: Butyrylcholinesterase, lipoxygenase inhibiting and antifungal alkaloids from Isatis tinctoria Ahmad I, Fatima I Ref: J Enzyme Inhib Med Chem, 23:313, 2008 : PubMed
Phytochemical investigations on the alkaloidal fraction of the whole plant of the Isatis tinctoria led to the isolation of the alkaloids 1-6. Compounds 3, 2 were found to be potent butyrylcholinesterase and lipoxygenase enzymes inhibitors in a concentration-dependent manner with the IC(50) values 16.3 +/- 0.06 and 19.7 +/- 0.03 microM against BChE and 30.6 +/- 0.02 and 33.7 +/- 0.05 microM against LOX, respectively. The compounds (1-6) showed significant antifungal activity against Trichophyton schoen leinii, Aspergillus niger, Candida albicans, Trichophyton simii, and Macrophomina phaseolina.
        
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Ahmad I, Fatima I (2008) Butyrylcholinesterase, lipoxygenase inhibiting and antifungal alkaloids from Isatis tinctoria J Enzyme Inhib Med Chem23: 313-6
Ahmad I, Fatima I (2008) J Enzyme Inhib Med Chem23: 313-6