Paper Report for: Akaaboune_1993_Neuromuscul.Disord_3_477
Reference
Title: The influence of denervation on beta-amyloid protein precursor and alpha 1-antichymotrypsin in mouse skeletal muscle Akaaboune M, Ma J, Festoff BW, Greenberg BD, Hantai D Ref: Neuromuscular Disorders, 3:477, 1993 : PubMed
A serpin, alpha 1-antichymotrypsin (alpha 1-ACT), and Kunitz inhibitor containing forms of the beta-amyloid precursor protein (beta APP) may be important components of the balance between serine proteases and inhibitors in the nervous system. In the current report we studied whether axotomy affected the localization of beta APP and alpha 1-ACT in adult mouse muscle. Immunocytochemical experiments indicated that beta APP was present in normal muscle both at neuromuscular junctions and within intramuscular nerves. alpha 1-ACT was also present at neuromuscular junctions, on the perineurium of nerves and endothelial cell surfaces. Following axotomy, both beta APP and alpha 1-ACT disappeared from intramuscular nerves simultaneously. However, at the neuromuscular junction alpha 1-ACT decreased more rapidly with beta APP lingering before disappearing.
        
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Akaaboune M, Ma J, Festoff BW, Greenberg BD, Hantai D (1993) The influence of denervation on beta-amyloid protein precursor and alpha 1-antichymotrypsin in mouse skeletal muscle Neuromuscular Disorders3: 477-81
Akaaboune M, Ma J, Festoff BW, Greenberg BD, Hantai D (1993) Neuromuscular Disorders3: 477-81