Paper Report for: Anderson_2004_Pestic.Biochem.Physiol_80_54
Reference
Title: Synergistic and antagonistic effects of atrazine on the toxicity of organophosphorodithioate and organophosphorothioate insecticides to Chironomus tentans (Diptera: Chironomidae) Anderson TD, Zhu KY Ref: Pesticide Biochemistry and Physiology, 80:54, 2004 : PubMed
The acute toxicities of two organophosphorodithioate (dimethoate and disulfoton) and two organophosphorothioate (omethoate and demeton-S-methyl) insecticides were evaluated individually and in binary combination with the herbicide atrazine using fourth-instar larvae of the aquatic midge, Chironomus tentans. Atrazine alone up to 1000 [mu]g/L did not show significant toxicity to the midges in a 48-h bioassay. However, atrazine concentrations as low as 1 [mu]g/L in combination with dimethoate at EC25 (concentration to affect 25% of tested midges), 100 [mu]g/L in combination with disulfoton (EC25), and 10 [mu]g/L in combination with demeton-S-methyl (EC25) significantly enhanced the toxicity of each organophosphate insecticide. In contrast, atrazine concentrations of 10 [mu]g/L and above in combination with omethoate (EC25) significantly decreased the toxicity of the insecticide. Biochemical analysis indicated that increased toxicity of dimethoate, disulfoton, and demeton-S-methyl in binary combination with atrazine correlated to the increased inhibition of acetylcholinesterase. Furthermore, cytochrome P450-dependent O-deethylation activity in the midges exposed to atrazine at 1000 [mu]g/L was 1.5-fold higher than that in the control midges. Thus, atrazine appeared to induce cytochrome P450 monooxygenases in the midges. Elevated cytochrome P450 monooxygenase activity may increase the toxicities of dimethoate, disulfoton, and demeton-S-methyl by enhancing the oxidative activation of dimethoate into omethoate, and disulfoton and demeton-S-methyl into their sulfoxide analogs with increased anticholinesterase activity. In contrast, atrazine reduced the toxicity of omethoate possibly by enhancing the oxidative metabolic detoxification since omethoate does not require oxidative activation.
        
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Anderson TD, Zhu KY (2004) Synergistic and antagonistic effects of atrazine on the toxicity of organophosphorodithioate and organophosphorothioate insecticides to Chironomus tentans (Diptera: Chironomidae) Pesticide Biochemistry and Physiology80: 54-64
Anderson TD, Zhu KY (2004) Pesticide Biochemistry and Physiology80: 54-64