Human butyrylcholinesterase (BChE, EC 3.1.1.8) or acetylcholinesterase (AChE, EC 3.1.1.7) from fetal bovine serum (FBS), administered i.v. in mice, sequestered at approximately 1:1 stoichiometry the highly toxic anti-ChE organophosphate, 1,2,2-trimethylpropyl methyl-fluorophosphonate (soman). A quantitative linear correlation was demonstrated between blood-ChE levels and the protection conferred by exogeneously administered ChE. Results presented here demonstrate that either human BChE or FBS-AChE is an effective prophylactic measure sufficient to protect mice from multiple LD50S of soman without the administration of post-treatment supportive drugs.
        
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Ashani Y, Shapira S, Levy D, Wolfe AD, Doctor BP, Raveh L (1991) Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice Biochemical Pharmacology41: 37-41
Ashani Y, Shapira S, Levy D, Wolfe AD, Doctor BP, Raveh L (1991) Biochemical Pharmacology41: 37-41