Paper Report for: Aura_1998_Eur.J.Pharmacol_342_15
Reference
Title: Tetrahydroaminoacridine and D-cycloserine stimulate acquisition of water maze spatial navigation in aged rats Aura J, Riekkinen M, Riekkinen P, Jr. Ref: European Journal of Pharmacology, 342:15, 1998 : PubMed
We investigated the effect of tetrahydroaminoacridine, a cholinesterase inhibitor and D-cycloserine (a partial glycine-B agonist of the NMDA receptor complex) on the defect of water maze spatial navigation in rats induced by aging. Tetrahydroaminoacridine (3 mg/kg, i.p.) or D-cycloserine (10 mg/kg, i.p.) enhanced acquisition of the water maze task. A combination of subthreshold doses of tetrahydroaminoacridine (1 mg/kg) and D-cycloserine (3 mg/kg) improved water maze acquisition, but a combination of lower subthreshold doses (tetrahydroaminoacridine 0.3 mg/kg + D-cycloserine 1 mg/kg) was ineffective. Consolidation in water maze test was not improved by tetrahydroaminoacridine (3 mg/kg) and/or D-cycloserine (10 mg/kg). The results suggest that tetrahydroaminoacridine and D-cycloserine synergistically enhance acquisition of spatial navigation in aged rats.
        
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Citations formats
Aura J, Riekkinen M, Riekkinen P, Jr. (1998) Tetrahydroaminoacridine and D-cycloserine stimulate acquisition of water maze spatial navigation in aged rats European Journal of Pharmacology342: 15-20
Aura J, Riekkinen M, Riekkinen P, Jr. (1998) European Journal of Pharmacology342: 15-20