Paper Report for: Bagetta_1993_Eur.J.Pharmacol_237_61
Reference
Title: Systemic administration of lithium chloride and tacrine increases nitric oxide synthase activity in the hippocampus of rats Bagetta G, Massoud R, Rodino P, Federici G, Nistico G Ref: European Journal of Pharmacology, 237:61, 1993 : PubMed
We planned to ascertain whether the administration of the anticholinesterase, tacrine (5 mg/kg i.p.), to rats pretreated 24 h before with lithium chloride (LiCl; 12 mEq/kg i.p.) produced any change in nitric oxide (NO) synthase activity in the hippocampus. A significant increase in hippocampal Ca(2+)-calmodulin-dependent NO synthase activity occurred 15 min after tacrine injection and was blocked by atropine (5 mg/kg i.p. given 15 min before tacrine) and by N omega-nitro-L-arginine methyl ester (300 micrograms given into one lateral cerebral ventricle 10 min before tacrine), a NO synthase inhibitor. A consistent cyclic guanosine 3',5'-monophosphate (cGMP) accumulation was also seen. In conclusion, the present results show that tacrine given to LiCl-pretreated rats produces a significant increase in NO synthase activity in the hippocampus and this may be responsible, at least in part, for seizures and related brain damage elicited by these drugs.
        
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Bagetta G, Massoud R, Rodino P, Federici G, Nistico G (1993) Systemic administration of lithium chloride and tacrine increases nitric oxide synthase activity in the hippocampus of rats European Journal of Pharmacology237: 61-4
Bagetta G, Massoud R, Rodino P, Federici G, Nistico G (1993) European Journal of Pharmacology237: 61-4