Paper Report for: Barnes_1985_Br.J.Pharmacol_86_685
Reference
Title: The effect of airway epithelium on smooth muscle contractility in bovine trachea Barnes PJ, Cuss FM, Palmer JB Ref: British Journal of Pharmacology, 86:685, 1985 : PubMed
In bovine tracheal smooth muscle the presence of airway epithelium significantly reduced the sensitivity and maximum contractile response to histamine, 5-hydroxytryptamine (5-HT) or acetylcholine. Muscle contraction induced by K+ and electrical field stimulation was of similar magnitude both in the presence or absence of adherent epithelium. The effect of epithelium on smooth muscle contractility was unaffected by pretreatment with indomethacin (10(-6) M) or mepacrine (5 X 10(-5) M). The relaxant response to isoprenaline was enhanced in the presence of epithelium, although this was significant only in the case of precontraction with 5-HT. It is concluded that the bronchial epithelium may produce a relaxant factor which is not a cyclooxygenase or lipoxygenase product. The production of this factor may be reduced or lost following epithelial damage and this may be important in the pathogenesis of bronchial hyperresponsiveness in asthma.
        
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Barnes PJ, Cuss FM, Palmer JB (1985) The effect of airway epithelium on smooth muscle contractility in bovine trachea British Journal of Pharmacology86: 685-91
Barnes PJ, Cuss FM, Palmer JB (1985) British Journal of Pharmacology86: 685-91