Paper Report for: Beitnere_2014_Eur.J.Pharmacol_745_76
Reference
Title: Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats Beitnere U, Dzirkale Z, Isajevs S, Rumaks J, Svirskis S, Klusa V Ref: European Journal of Pharmacology, 745:76, 2014 : PubMed
The present study investigates the efficacy of mildronate, a carnitine congener, to protect stress and haloperidol-induced impairment of memory in rats and the expression of brain protein biomarkers involved in synaptic plasticity, such as brain-derived neurotrophic factor (BDNF), acetylcholine esterase and glutamate decarboxylase 67 (GAD67). Two amnesia models were used: 2h immobilization stress and 3-week haloperidol treatment. Stress caused memory impairment in the passive avoidance test and induced a significant 2-fold BDNF elevation in hippocampal and striatal tissues that was completely inhibited by mildronate. Mildronate decreased the level of GAD67 (but not acetylcholine esterase) expression by stress. Haloperidol decrease by a third hippocampal BDNF and acetylcholine esterase (but not GAD67) expression, which was normalized by mildronate; it also reversed the haloperidol-induced memory impairment in Barnes test. The results suggest the usefulness of mildronate as protector against neuronal disturbances caused by stress or haloperidol.
        
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Citations formats
Beitnere U, Dzirkale Z, Isajevs S, Rumaks J, Svirskis S, Klusa V (2014) Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats European Journal of Pharmacology745: 76-83
Beitnere U, Dzirkale Z, Isajevs S, Rumaks J, Svirskis S, Klusa V (2014) European Journal of Pharmacology745: 76-83