Acetylcholinesterase (ACE) activity and lipid peroxidation (LPO) parameters were measured in the blood of patients with Alzheimer's disease (AD) during treatment with amiridine and gliatiline. Treatment was accompanied by inhibition of ACE. There was a statistically significant relationship between clinical efficacy and changes in ACE activity. AD was charactefized by significant changes in LPO parameters, with a three-fold increase in the level of primary oxidation products on the background of a sharp (seven-fold) increase in total lipid desaturatedness. There was a statistically significant relationship between ACE activity and the levels of primary oxidation products in the RBC of patients with AD before and after treatment with amiridine and gliatiline.
        
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Braginskaya FI, Zorina M, Pal'mina NP, Gaintseva VD, Burlakova EB, Selezneva ND, Kolykhalov IV, Gavrilova SI (2001) Some blood biochemistry parameters during the cholinergic treatment of Alzheimer's disease Neurosci Behav Physiol31: 457-61
Braginskaya FI, Zorina M, Pal'mina NP, Gaintseva VD, Burlakova EB, Selezneva ND, Kolykhalov IV, Gavrilova SI (2001) Neurosci Behav Physiol31: 457-61