In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. The compounds show excellent results as acetylcholinesterase inhibitors, being as active as the standard drug. All these compounds also show very good antioxidant activity through different mechanisms of action.
        
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Canto RF, Barbosa FA, Nascimento V, de Oliveira AS, Brighente IM, Braga AL (2014) Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease Org Biomol Chem12: 3470-7
Canto RF, Barbosa FA, Nascimento V, de Oliveira AS, Brighente IM, Braga AL (2014) Org Biomol Chem12: 3470-7