Paper Report for: Carboni_1989_Psychopharmacology.(Berl)_97_175
Reference
Title: 5HT3 receptor antagonists block morphine- and nicotine- but not amphetamine-induced reward Carboni E, Acquas E, Leone P, Di Chiara G Ref: Psychopharmacology (Berl), 97:175, 1989 : PubMed
The effect of two potent and specific antagonists of 5HT3 receptors, ICS 205-930 and MDL 72222, on the reinforcing properties of amphetamine, morphine and nicotine was studied in rats. Drug-induced reinforcement was assessed by measuring drug-conditioned place preference. ICS 205-930 and MDL 72222 dose-dependently reduced the place preference induced by morphine (1.0 mg/kg SC). At doses of 0.030 mg/kg SC the two antagonists completely blocked morphine-induced place preference while doses of 0.015 mg/kg SC significantly reduced it. ICS 205-930 and MDL 72222 at doses of 0.030 mg/kg SC also prevented the place preference induced by nicotine (0.6 mg/kg SC). In contrast, ICS 205-930 and MDL 72222 up to doses of 0.030 mg/kg SC failed to modify the place preference elicited by amphetamine (1.0 mg/kg SC). The results indicate that 5HT3 receptors are specifically involved in the reinforcing properties of morphine and nicotine.
        
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Carboni E, Acquas E, Leone P, Di Chiara G (1989) 5HT3 receptor antagonists block morphine- and nicotine- but not amphetamine-induced reward Psychopharmacology (Berl)97: 175-8
Carboni E, Acquas E, Leone P, Di Chiara G (1989) Psychopharmacology (Berl)97: 175-8