Paper Report for: Cervini_1995_J.Biol.Chem_270_24654
Reference
Title: Specific vesicular acetylcholine transporter promoters lie within the first intron of the rat choline acetyltransferase gene Cervini R, Houhou L, Pradat PF, Bejanin S, Mallet J, Berrard S Ref: Journal of Biological Chemistry, 270:24654, 1995 : PubMed
The sequence encoding the vesicular acetylcholine transporter (VAChT) has recently been localized within the first intron of the choline acetyltransferase (ChAT) gene in various species. In rat, we previously identified a class of VAChT mRNAs that may originate from the same promoter region as two ChAT mRNAs. Here, we demonstrate by a detailed analysis of the 5'-noncoding region of the VAChT gene, that two specific VAChT promoters lie within the first intron of the ChAT gene. Two VAChT mRNAs are generated from these promoters. These results demonstrate that the promoter regions of these two genes are intermingled, which highlight the unique organization of the ChAT/VAChT gene locus.
        
Related information
Citations formats
Cervini R, Houhou L, Pradat PF, Bejanin S, Mallet J, Berrard S (1995) Specific vesicular acetylcholine transporter promoters lie within the first intron of the rat choline acetyltransferase gene Journal of Biological Chemistry270: 24654-7
Cervini R, Houhou L, Pradat PF, Bejanin S, Mallet J, Berrard S (1995) Journal of Biological Chemistry270: 24654-7