Title: Role of detoxication pathways in acute toxicity levels of phosphorothionate insecticides in the rat Chambers JE, Ma T, Boone JS, Chambers HW Ref: Life Sciences, 54:1357, 1994 : PubMed
Phosphorothionate insecticides and their active oxon metabolites can be detoxified by a variety of hepatic mechanisms. Cytochrome P450-mediated dearylation activity was higher in males than in females. While dearylation was induced by phenobarbital in both sexes, it was induced by beta-naphthoflavone in females only. Detoxication of oxons in the presence of EDTA was inducible by phenobarbital, was higher in males than in females, and paralleled aliesterase activity. In vitro Ca(++)-dependent A-esterase-mediated hydrolysis of chlorpyrifos-oxon but not of paraoxon occurred at biologically relevant nM concentrations. This hydrolysis was also inducible by phenobarbital. Glutathione-mediated conjugation did not appear to be relevant to the disposition of the phosphorothionates studied here. Hepatic detoxication via dearylation, aliesterase phosphorylation and A-esterase-mediated hydrolysis (for some organophosphates) all appear to be relevant reactions in the attenuation of acute toxicity.
        
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Chambers JE, Ma T, Boone JS, Chambers HW (1994) Role of detoxication pathways in acute toxicity levels of phosphorothionate insecticides in the rat Life Sciences54: 1357-64
Chambers JE, Ma T, Boone JS, Chambers HW (1994) Life Sciences54: 1357-64