Paper Report for: Cho_2006_Biol.Pharm.Bull_29_2317
Reference
Title: 8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L Cho KM, Yoo ID, Kim WG Ref: Biol Pharm Bull, 29:2317, 2006 : PubMed
Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (AChE) activity without a significant inhibition of butyrylcholinesterase (BuChE). Using mass spectrometry and NMR studies, three active constituents were isolated and identified: 8-hydroxydihydrochelerythrine (1), 8-hydroxydihydrosanguinarine (2), and berberine (3). Compounds 1-3 showed potent inhibitory activity against AChE, with IC50 (microM) values of 0.61-1.85. Compound 1 exhibited competitive and selective inhibition for AChE.
Cho KM, Yoo ID, Kim WG (2006) 8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L Biol Pharm Bull29: 2317-20
Cho KM, Yoo ID, Kim WG (2006) Biol Pharm Bull29: 2317-20
