Paper Report for: Cole_1998_Nature_393_537 Reference
Title: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole ST , Brosch R , Parkhill J , Garnier T , Churcher C , Harris D , Gordon SV , Eiglmeier K , Gas S and Barrell BG <32 more author(s)> Cole ST , Brosch R , Parkhill J , Garnier T , Churcher C , Harris D , Gordon SV , Eiglmeier K , Gas S , Barry CE, 3rd , Tekaia F , Badcock K , Basham D , Brown D , Chillingworth T , Connor R , Davies R , Devlin K , Feltwell T , Gentles S , Hamlin N , Holroyd S , Hornsby T , Jagels K , Krogh A , McLean J , Moule S , Murphy L , Oliver K , Osborne J , Quail MA , Rajandream MA , Rogers J , Rutter S , Seeger K , Skelton J , Squares R , Squares S , Sulston JE , Taylor K , Whitehead S , Barrell BG (- 32) Ref: Nature,
393 :537, 1998 :
PubMed Abstract PubMedSearch: Cole 1998 Nature 393 537 PubMedID: 9634230 Gene_locus related to this paper: myctu-a85a ,
myctu-a85b ,
myctu-a85c ,
myctu-bpoC ,
myctu-cut3 ,
myctu-cutas1 ,
myctu-cutas2 ,
myctu-d5yk66 ,
myctu-ephA ,
myctu-ephB ,
myctu-ephc ,
myctu-ephd ,
myctu-ephE ,
myctu-ephF ,
myctu-hpx ,
myctu-linb ,
myctu-lipG ,
myctu-lipJ ,
myctu-LIPS ,
myctu-lipv ,
myctu-LPQC ,
myctu-LPQP ,
myctu-MBTB ,
myctu-metx ,
myctu-mpt51 ,
myctu-MT1628 ,
myctu-MT3441 ,
myctu-p71654 ,
myctu-p95011 ,
myctu-PKS6 ,
myctu-PKS13 ,
myctu-ppe42 ,
myctu-ppe63 ,
myctu-Rv1430 ,
myctu-RV0045C ,
myctu-Rv0077c ,
myctu-Rv0151c ,
myctu-Rv0152c ,
myctu-Rv0159c ,
myctu-Rv0160c ,
myctu-rv0183 ,
myctu-Rv0217c ,
myctu-Rv0220 ,
myctu-Rv0272c ,
myctu-RV0293C ,
myctu-RV0421C ,
myctu-RV0457C ,
myctu-RV0519C ,
myctu-RV0774C ,
myctu-RV0782 ,
myctu-RV0840C ,
myctu-Rv1069c ,
myctu-Rv1076 ,
myctu-RV1123C ,
myctu-Rv1184c ,
myctu-Rv1190 ,
myctu-Rv1191 ,
myctu-RV1192 ,
myctu-RV1215C ,
myctu-Rv1399c ,
myctu-Rv1400c ,
myctu-Rv1426c ,
myctu-RV1639C ,
myctu-RV1683 ,
myctu-RV1758 ,
myctu-Rv1800 ,
myctu-Rv1833c ,
myctu-RV2054 ,
myctu-RV2296 ,
myctu-Rv2385 ,
myctu-Rv2485c ,
myctu-RV2627C ,
myctu-RV2672 ,
myctu-RV2695 ,
myctu-RV2765 ,
myctu-RV2800 ,
myctu-RV2854 ,
myctu-Rv2970c ,
myctu-Rv3084 ,
myctu-Rv3097c ,
myctu-rv3177 ,
myctu-Rv3312c ,
myctu-RV3452 ,
myctu-RV3473C ,
myctu-Rv3487c ,
myctu-Rv3569c ,
myctu-Rv3591c ,
myctu-RV3724 ,
myctu-Rv3802c ,
myctu-Rv3822 ,
myctu-y0571 ,
myctu-y963 ,
myctu-Y1834 ,
myctu-y1835 ,
myctu-y2079 ,
myctu-Y2307 ,
myctu-yc88 ,
myctu-ym23 ,
myctu-ym24 ,
myctu-YR15 ,
myctu-yt28 Abstract
Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.
Related information
Gene_Locus | myctu-a85a , myctu-a85b , myctu-a85c , myctu-bpoC , myctu-cut3 , myctu-cutas1 , myctu-cutas2 , myctu-d5yk66 , myctu-ephA , myctu-ephB , myctu-ephc , myctu-ephd , myctu-ephE , myctu-ephF , myctu-hpx , myctu-linb , myctu-lipG , myctu-lipJ , myctu-LIPS , myctu-lipv , myctu-LPQC , myctu-LPQP , myctu-MBTB , myctu-metx , myctu-mpt51 , myctu-MT1628 , myctu-MT3441 , myctu-p71654 , myctu-p95011 , myctu-PKS6 , myctu-PKS13 , myctu-ppe42 , myctu-ppe63 , myctu-Rv1430 , myctu-RV0045C , myctu-Rv0077c , myctu-Rv0151c , myctu-Rv0152c , myctu-Rv0159c , myctu-Rv0160c , myctu-rv0183 , myctu-Rv0217c , myctu-Rv0220 , myctu-Rv0272c , myctu-RV0293C , myctu-RV0421C , myctu-RV0457C , myctu-RV0519C , myctu-RV0774C , myctu-RV0782 , myctu-RV0840C , myctu-Rv1069c , myctu-Rv1076 , myctu-RV1123C , myctu-Rv1184c , myctu-Rv1190 , myctu-Rv1191 , myctu-RV1192 , myctu-RV1215C , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-RV1639C , myctu-RV1683 , myctu-RV1758 , myctu-Rv1800 , myctu-Rv1833c , myctu-RV2054 , myctu-RV2296 , myctu-Rv2385 , myctu-Rv2485c , myctu-RV2627C , myctu-RV2672 , myctu-RV2695 , myctu-RV2765 , myctu-RV2800 , myctu-RV2854 , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-rv3177 , myctu-Rv3312c , myctu-RV3452 , myctu-RV3473C , myctu-Rv3487c , myctu-Rv3569c , myctu-Rv3591c , myctu-RV3724 , myctu-Rv3802c , myctu-Rv3822 , myctu-y0571 , myctu-y963 , myctu-Y1834 , myctu-y1835 , myctu-y2079 , myctu-Y2307 , myctu-yc88 , myctu-ym23 , myctu-ym24 , myctu-YR15 , myctu-yt28
Citations formats
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE, 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG (1998) Nature 393 : 537-44Nature 393 : 537-44
