Title: Identification of m3, m4 and m5 subtypes of muscarinic receptor mRNA in human blood mononuclear cells Costa Paola, Auger CB, Traver DJ, Costa LG Ref: Journal of Neuroimmunology, 60:45, 1995 : PubMed
In this study we made use of the Reverse transcription-polymerase chain reaction to analyze the expression of mRNA for the five subtypes of muscarinic acetylcholine receptors in human blood mononuclear cells. mRNA for m3, m4 and m5 subtypes was detected, while mRNA for m1 and m2 muscarinic receptors was not found. Similar results were obtained for three different healthy human subjects studied. Interestingly, the m5 subtype was expressed at higher levels in blood mononuclear cells than in cerebral cortex. To our knowledge this is the first time that m5 muscarinic receptor mRNA has been found outside of the central nervous system.
        
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Costa Paola, Auger CB, Traver DJ, Costa LG (1995) Identification of m3, m4 and m5 subtypes of muscarinic receptor mRNA in human blood mononuclear cells Journal of Neuroimmunology60: 45-51
Costa Paola, Auger CB, Traver DJ, Costa LG (1995) Journal of Neuroimmunology60: 45-51