Paper Report for: Costa_2013_J.Hazard.Mater_265C_133
Reference
Title: Automated evaluation of pharmaceutically active ionic liquids' (eco)toxicity through the inhibition of human carboxylesterase and Vibrio fischeri Costa SP, Justina VD, Bica K, Vasiloiu M, Pinto PC, Saraiva ML Ref: J Hazard Mater, 265C:133, 2013 : PubMed
The toxicity of 16 pharmaceutical active ionic liquids (IL-APIs) was evaluated by automated approaches based on sequential injection analysis (SIA). The implemented bioassays were centered on the inhibition of human carboxylesterase 2 and Vibrio fischeri, in the presence of the tested compounds. The inhibitory effects were quantified by calculating the inhibitor concentration required to cause 50% of inhibition (EC50). The EC50 values demonstrated that the cetylpyridinium group was one of the most toxic cations and that the imidazolium group was the less toxic. The obtained results provide important information about the safety of the studied IL-APIs and their possible use as pharmaceutical drugs. The developed automated SIA methodologies are robust screening bioassays, and can be used as a generic tools to identify the (eco)toxicity of the structural elements of ILs, contributing to a sustainable development of drugs.
        
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Citations formats
Costa SP, Justina VD, Bica K, Vasiloiu M, Pinto PC, Saraiva ML (2013) Automated evaluation of pharmaceutically active ionic liquids' (eco)toxicity through the inhibition of human carboxylesterase and Vibrio fischeri J Hazard Mater265C: 133-141
Costa SP, Justina VD, Bica K, Vasiloiu M, Pinto PC, Saraiva ML (2013) J Hazard Mater265C: 133-141