Paper Report for: Coulson_2009_Neuroscientist_15_317
Reference
Title: The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease Coulson EJ, May LM, Sykes AM, Hamlin AS Ref: Neuroscientist, 15:317, 2009 : PubMed
Degeneration of basal forebrain cholinergic neurons is a common feature of Alzheimer's disease and is proposed to be an early and key event in the condition's etiology. This review discusses recent findings that strongly link the p75 neurotrophin receptor (p75(NTR)) to both cholinergic neuron degeneration and the production of toxic forms of amyloid-beta (Abeta), which is found deposited as amyloid plaques in the brains of Alzheimer's disease patients. Although elucidating the underlying molecular mechanisms and the clinical significance of these findings will require further experimentation, a number of possible scenarios and future research directions are presented.
        
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Coulson EJ, May LM, Sykes AM, Hamlin AS (2009) The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease Neuroscientist15: 317-23
Coulson EJ, May LM, Sykes AM, Hamlin AS (2009) Neuroscientist15: 317-23