Paper Report for: Dai_2009_Biomacromolecules_10_3176
Reference
Title: Enzyme-catalyzed polycondensation of polyester macrodiols with divinyl adipate: a green method for the preparation of thermoplastic block copolyesters Dai S, Xue L, Zinn M, Li Z Ref: Biomacromolecules, 10:3176, 2009 : PubMed
Enzyme-catalyzed polycondensation for the synthesis of block copolymers was reported for the first time. Thermoplastic block copolyesters containing poly[(R)-3-hydroxybutyrate] (PHB) and poly[(R)-3-hydroxyoctanoate] (PHO) blocks were enzymatically prepared by one- or two-step lipase-catalyzed polycondensation. Novozym 435-catalyzed reaction of PHB-diol (M(n) of 3100 g/mol, GPC), PHO-diol (M(n) of 3200 g/mol, GPC), and divinyl adipate gave block poly(HB-co-HO) (M(n) of 9800 g/mol, GPC) with randomly arranged blocks in 55% yield. In two-step polycondensations, Novozym 435-catalyzed reaction of PHB-diol and divinyl adipate afforded 73% of PHB containing two vinyl ester end groups (M(n) of 2700 g/mol, GPC), which was further reacted with PHO-diol in the presence of Novozym 435 to give block poly(HB-co-HO)s (M(n) of 8800-14 200 g/mol, GPC) with A-B-type arranged blocks in 55-62% yield. The enzymatically prepared block copolyesters demonstrated T(m) of 136-142 degrees C and 142-153 degrees C and T(g) of -37 to -39 degrees C and were potentially useful thermoplastic biodegradable and biocompatible materials.
        
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Citations formats
Dai S, Xue L, Zinn M, Li Z (2009) Enzyme-catalyzed polycondensation of polyester macrodiols with divinyl adipate: a green method for the preparation of thermoplastic block copolyesters Biomacromolecules10: 3176-81
Dai S, Xue L, Zinn M, Li Z (2009) Biomacromolecules10: 3176-81