Paper Report for: Dascal_1985_Proc.Natl.Acad.Sci.U.S.A_82_6001
Reference
Title: Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes Dascal N, Lotan I, Gillo B, Lester HA, Lass Y Ref: Proc Natl Acad Sci U S A, 82:6001, 1985 : PubMed
In Xenopus laevis oocytes, adenosine and other purinergic agonists induce a K+-conductance increase that is fully mimicked by intracellular application of cAMP. Acetylcholine suppresses the K+-conductance increase caused by adenosine, by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine, or by intracellular injection of cAMP. This effect of acetylcholine is not mimicked by intracellular injection of Ca2+ or of the Ca-mobilizing agent inositol 1,4,5-trisphosphate. However, adenosine and cAMP responses are inhibited by 4 beta-phorbol 12,13-dibutyrate and 4 beta-phorbol 12-myristate 13-acetate. These results suggest that, in Xenopus oocytes, the muscarinic inhibition of purinergic and cAMP responses is mediated through the activation of the phospholipid-dependent, Ca-activated protein kinase (protein kinase C).
        
Related information
Citations formats
Dascal N, Lotan I, Gillo B, Lester HA, Lass Y (1985) Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes Proc Natl Acad Sci U S A82: 6001-5
Dascal N, Lotan I, Gillo B, Lester HA, Lass Y (1985) Proc Natl Acad Sci U S A82: 6001-5