Paper Report for: Degen_1999_Bioorg.Med.Chem.Lett_9_973
Reference
Title: Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin Degen SJ, Mueller KL, Shen HC, Mulder JA, Golding GM, Wei LL, Zificsak CA, Neeno-Eckwall A, Hsung RP Ref: Bioorganic & Medicinal Chemistry Lett, 9:973, 1999 : PubMed
A general approach to synthesis of dihydroxanthone derivatives is described here. In vitro evaluation of these dihydroxanthones demonstrated that some derivatives possess moderate anti-cholinesterase activities and better selectivities than tacrine for acetylcholinesterase over butyrylcholinesterase. Structural effects on anti-cholinesterase activities were also examined, and docking experiments were carried out to provide preliminary understandings of these experimental observations.
Degen SJ, Mueller KL, Shen HC, Mulder JA, Golding GM, Wei LL, Zificsak CA, Neeno-Eckwall A, Hsung RP (1999) Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin Bioorganic & Medicinal Chemistry Lett9: 973-8
Degen SJ, Mueller KL, Shen HC, Mulder JA, Golding GM, Wei LL, Zificsak CA, Neeno-Eckwall A, Hsung RP (1999) Bioorganic & Medicinal Chemistry Lett9: 973-8