Title: Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099 Ding Y, Yu Y, Pan H, Guo H, Li Y, Liu W Ref: Mol Biosyst, 6:1180, 2010 : PubMed
Characterization of the biosynthetic gene cluster of glycosylated antibiotic nocathiacin I (NOC-I) here adds new insights to thiopeptide biosynthesis, showing the NOC-specific tailoring and unusual sugar formation. NOC-I biosynthesis shares the paradigm for forming a common thiopeptide core and the generality for converting to an e series member, as that of the parent compound nosiheptide (NOS). This may permit the production of NOC-I in the genetically amenable, NOS-producing strain by building NOC-specific genes for pathway engineering.
Ding Y, Yu Y, Pan H, Guo H, Li Y, Liu W (2010) Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099 Mol Biosyst6: 1180-5
Ding Y, Yu Y, Pan H, Guo H, Li Y, Liu W (2010) Mol Biosyst6: 1180-5