Title: Theracurmin supplementation may be a therapeutic option for older patients with Alzheimer's disease: a 6-month retrospective follow-up study Dost FS, Kaya D, Ontan MS, Erken N, Bulut EA, Aydin AE, Isik AT Ref: Curr Alzheimer Res, :, 2021 : PubMed
BACKGROUND: Alzheimer's Disease (AD) is still a great global challenge and agents with various mechanisms represent a promising therapeutic opportunity. Theracurmin, a very highly absorbable curcumin formulation, was shown to improve memory and attention in non-demented people. OBJECTIVE: To investigate the effect of Theracurmin on disease course in elderly patients with mild cognitive impairment (MCI) and AD. METHODS: This follow-up study was performed retrospectively on 93 patients with MCI or AD. All patients underwent comprehensive geriatric assessment, including Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MOCA), clock-drawing test, activities of daily living (ADL), at baseline and end of the 6th-month. 19 patients with AD and 17 with MCI were treated with Theracurmin 180 mg/day per oral. RESULTS: MMSE, MOCA and instrumental ADL scores decreased in AD patients that were not treated with Theracurmin (p<0.001, p=0.011, and p=0.004, respectively), whereas these scores remained stable in those treated with Theracurmin. This stabilization in the instrumental ADL was also observed in MCI patients treated with Theracurmin. During the follow-up, three of MCI patients who did not receive Theracurmin progressed to AD, whereas only one patient progressed in those who received it. CONCLUSION: Theracurmin seems to be a therapeutic option for elderly patients with AD and MCI via providing stabilization of the disease course by preventing progressive loss in cognitive functions and ADLs.
        
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Dost FS, Kaya D, Ontan MS, Erken N, Bulut EA, Aydin AE, Isik AT (2021) Theracurmin supplementation may be a therapeutic option for older patients with Alzheimer's disease: a 6-month retrospective follow-up study Curr Alzheimer Res
Dost FS, Kaya D, Ontan MS, Erken N, Bulut EA, Aydin AE, Isik AT (2021) Curr Alzheimer Res