Paper Report for: Dudai_1973_Proc.Natl.Acad.Sci.U.S.A_70_2473
Reference
Title: Molecular structures of acetylcholinesterase from electric organ tissue of the electric eel Dudai Y, Herzberg M, Silman I Ref: Proceedings of the National Academy of Sciences of the United States of America, 70:2473, 1973 : PubMed
Three purified molecular forms of acetylcholinesterase (EC 3.1.1.7) with sedimentation coefficients of 18 S, 14 S, and 11 S were studied by analytical ultracentrifugation and electron microscopy. The three species have molecular weights of (1.1 +/- 0.1) x 10(6), (7.5 +/- 1.5) x 10(5), and (3.35 +/- 0.25) x 10(5), respectively. Electron micrographs reveal that the 18S and 14S forms are asymmetric, composed of a head, containing a large number of subunits, and an elongated tail. The 11S form of acetylcholinesterase is apparently a tetrameric structure devoid of the tail. Maleylation of 18S and 14S acetylcholinesterases abolishes their tendency to aggregate at low ionic strength.
        
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Dudai Y, Herzberg M, Silman I (1973) Molecular structures of acetylcholinesterase from electric organ tissue of the electric eel Proceedings of the National Academy of Sciences of the United States of America70: 2473-6
Dudai Y, Herzberg M, Silman I (1973) Proceedings of the National Academy of Sciences of the United States of America70: 2473-6