Paper Report for: Durieux_2016_J.Neurophysiol_115_5
Reference
Title: Neuroligin-2 and the tightrope of excitation/inhibition balance in the prefrontal cortex Durieux AM, Horder J, Petrinovic MM Ref: Journal of Neurophysiology, 115:5, 2016 : PubMed
Excitation/inhibition imbalance is implicated in symptoms of neuropsychiatric disorders. We discuss a study by Liang et al. (Mol Psychiatry 20: 850-859, 2015) demonstrating that the conditional knockout of neuroligin-2, a postsynaptic adhesion protein, in the prefrontal cortex of adult mice results in alterations in inhibitory synaptic properties. However, behavioral impairments emerged prior to the development of detectable changes in excitation/inhibition ratio. This suggests there may be network-specific excitation/inhibition ratios, some of which are more vulnerable to disruption than others.
        
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Durieux AM, Horder J, Petrinovic MM (2016) Neuroligin-2 and the tightrope of excitation/inhibition balance in the prefrontal cortex Journal of Neurophysiology115: 5-7
Durieux AM, Horder J, Petrinovic MM (2016) Journal of Neurophysiology115: 5-7