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Paper Report for: Eiamthong_2022_Angew.Chem.Int.Ed.Engl_15_e202203061

Reference

Title: Discovery and Genetic Code Expansion of a Polyethylene Terephthalate (PET) Hydrolase from the Human Saliva Metagenome for the Degradation and Bio-Functionalization of PET
Eiamthong B, Meesawat P, Wongsatit T, Jitdee J, Sangsri R, Patchsung M, Aphicho K, Suraritdechachai S, Huguenin-Dezot N and Uttamapinant C <7 more author(s)>
Ref: Angew Chem Int Ed Engl, :e202203061, 2022 : PubMed

        



Comment
MG8, from the human saliva metagenome has robust PET plastic degradation activities under different temperature and salinity conditions, outperforming several naturally occurring and engineered hydrolases in degrading PET. By encoding 2,3-diaminopropionic acid (DAP) in place of the catalytic serine of MG8, this non-canonical amino acid was used to covalently trap the acyl-enzyme intermediate of MG8. So this PET-degrading enzyme was converted into a covalent binder of PET. MG8(DAP) covalently captures instead of degrading PET



Citations formats

Eiamthong B, Meesawat P, Wongsatit T, Jitdee J, Sangsri R, Patchsung M, Aphicho K, Suraritdechachai S, Huguenin-Dezot N, Tang S, Suginta W, Paosawatyanyong B, Babu MM, Chin JW, Pakotiprapha D, Bhanthumnavin W, Uttamapinant C (2022)
Discovery and Genetic Code Expansion of a Polyethylene Terephthalate (PET) Hydrolase from the Human Saliva Metagenome for the Degradation and Bio-Functionalization of PET
Angew Chem Int Ed Engl

Eiamthong B, Meesawat P, Wongsatit T, Jitdee J, Sangsri R, Patchsung M, Aphicho K, Suraritdechachai S, Huguenin-Dezot N, Tang S, Suginta W, Paosawatyanyong B, Babu MM, Chin JW, Pakotiprapha D, Bhanthumnavin W, Uttamapinant C (2022)
Angew Chem Int Ed Engl



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