Paper Report for: El-Sayed_2005_Science_309_409 Reference
Title: The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
El-Sayed NM , Myler PJ , Bartholomeu DC , Nilsson D , Aggarwal G , Tran AN , Ghedin E , Worthey EA , Delcher AL and Andersson B <72 more author(s)> El-Sayed NM , Myler PJ , Bartholomeu DC , Nilsson D , Aggarwal G , Tran AN , Ghedin E , Worthey EA , Delcher AL , Blandin G , Westenberger SJ , Caler E , Cerqueira GC , Branche C , Haas B , Anupama A , Arner E , Aslund L , Attipoe P , Bontempi E , Bringaud F , Burton P , Cadag E , Campbell DA , Carrington M , Crabtree J , Darban H , da Silveira JF , de Jong P , Edwards K , Englund PT , Fazelina G , Feldblyum T , Ferella M , Frasch AC , Gull K , Horn D , Hou L , Huang Y , Kindlund E , Klingbeil M , Kluge S , Koo H , Lacerda D , Levin MJ , Lorenzi H , Louie T , Machado CR , McCulloch R , McKenna A , Mizuno Y , Mottram JC , Nelson S , Ochaya S , Osoegawa K , Pai G , Parsons M , Pentony M , Pettersson U , Pop M , Ramirez JL , Rinta J , Robertson L , Salzberg SL , Sanchez DO , Seyler A , Sharma R , Shetty J , Simpson AJ , Sisk E , Tammi MT , Tarleton R , Teixeira S , Van Aken S , Vogt C , Ward PN , Wickstead B , Wortman J , White O , Fraser CM , Stuart KD , Andersson B (- 72) Ref: Science,
309 :409, 2005 :
PubMed Abstract PubMedSearch: El-Sayed 2005 Science 309 409 PubMedID: 16020725 Gene_locus related to this paper: tryb2-q6h9e3 ,
tryb2-q6ha27 ,
tryb2-q38cd5 ,
tryb2-q38cd6 ,
tryb2-q38cd7 ,
tryb2-q38dc1 ,
tryb2-q38de4 ,
tryb2-q38ds6 ,
tryb2-q38dx1 ,
tryb2-q380z6 ,
tryb2-q382l4 ,
tryb2-q383a9 ,
tryb2-q386e3 ,
tryb2-q387r7 ,
tryb2-q388n1 ,
tryb2-q389w3 ,
trybr-PEPTB ,
trycr-q4cq28 ,
trycr-q4cq94 ,
trycr-q4cq95 ,
trycr-q4cq96 ,
trycr-q4cqq5 ,
trycr-q4csm0 ,
trycr-q4cwv3 ,
trycr-q4cx66 ,
trycr-q4cxr6 ,
trycr-q4cyc3 ,
trycr-q4cyc5 ,
trycr-q4cyf6 ,
trycr-q4czy3 ,
trycr-q4d1s2 ,
trycr-q4d2n1 ,
trycr-q4d3a2 ,
trycr-q4d3x3 ,
trycr-q4d3y4 ,
trycr-q4d6h1 ,
trycr-q4d8h8 ,
trycr-q4d8h9 ,
trycr-q4d8i0 ,
trycr-q4d786 ,
trycr-q4d975 ,
trycr-q4da08 ,
trycr-q4dab1 ,
trycr-q4dap6 ,
trycr-q4dap7 ,
trycr-q4dbm2 ,
trycr-q4dbn1 ,
trycr-q4ddw7 ,
trycr-q4de42 ,
trycr-q4dhn8 ,
trycr-q4dkk8 ,
trycr-q4dkk9 ,
trycr-q4dm56 ,
trycr-q4dp03 ,
trycr-q4dqa6 ,
trycr-q4dry8 ,
trycr-q4dt91 ,
trycr-q4dvl8 ,
trycr-q4dvp1 ,
trycr-q4dvp2 ,
trycr-q4dw34 ,
trycr-q4dwm3 ,
trycr-q4dy49 ,
trycr-q4dy82 ,
trycr-q4dzp6 ,
trycr-q4e3m8 ,
trycr-q4e4t5 ,
trycr-q4e5d1 ,
trycr-q4e5z2 ,
trycr-q6y3z8 ,
trycr-Q94795 ,
trycr-TCPO Abstract
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
Related information
Gene_Locus | tryb2-q6h9e3 , tryb2-q6ha27 , tryb2-q38cd5 , tryb2-q38cd6 , tryb2-q38cd7 , tryb2-q38dc1 , tryb2-q38de4 , tryb2-q38ds6 , tryb2-q38dx1 , tryb2-q380z6 , tryb2-q382l4 , tryb2-q383a9 , tryb2-q386e3 , tryb2-q387r7 , tryb2-q388n1 , tryb2-q389w3 , trybr-PEPTB , trycr-q4cq28 , trycr-q4cq94 , trycr-q4cq95 , trycr-q4cq96 , trycr-q4cqq5 , trycr-q4csm0 , trycr-q4cwv3 , trycr-q4cx66 , trycr-q4cxr6 , trycr-q4cyc3 , trycr-q4cyc5 , trycr-q4cyf6 , trycr-q4czy3 , trycr-q4d1s2 , trycr-q4d2n1 , trycr-q4d3a2 , trycr-q4d3x3 , trycr-q4d3y4 , trycr-q4d6h1 , trycr-q4d8h8 , trycr-q4d8h9 , trycr-q4d8i0 , trycr-q4d786 , trycr-q4d975 , trycr-q4da08 , trycr-q4dab1 , trycr-q4dap6 , trycr-q4dap7 , trycr-q4dbm2 , trycr-q4dbn1 , trycr-q4ddw7 , trycr-q4de42 , trycr-q4dhn8 , trycr-q4dkk8 , trycr-q4dkk9 , trycr-q4dm56 , trycr-q4dp03 , trycr-q4dqa6 , trycr-q4dry8 , trycr-q4dt91 , trycr-q4dvl8 , trycr-q4dvp1 , trycr-q4dvp2 , trycr-q4dw34 , trycr-q4dwm3 , trycr-q4dy49 , trycr-q4dy82 , trycr-q4dzp6 , trycr-q4e3m8 , trycr-q4e4t5 , trycr-q4e5d1 , trycr-q4e5z2 , trycr-q6y3z8 , trycr-Q94795 , trycr-TCPO
Citations formats
El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran AN, Ghedin E, Worthey EA, Delcher AL, Blandin G, Westenberger SJ, Caler E, Cerqueira GC, Branche C, Haas B, Anupama A, Arner E, Aslund L, Attipoe P, Bontempi E, Bringaud F, Burton P, Cadag E, Campbell DA, Carrington M, Crabtree J, Darban H, da Silveira JF, de Jong P, Edwards K, Englund PT, Fazelina G, Feldblyum T, Ferella M, Frasch AC, Gull K, Horn D, Hou L, Huang Y, Kindlund E, Klingbeil M, Kluge S, Koo H, Lacerda D, Levin MJ, Lorenzi H, Louie T, Machado CR, McCulloch R, McKenna A, Mizuno Y, Mottram JC, Nelson S, Ochaya S, Osoegawa K, Pai G, Parsons M, Pentony M, Pettersson U, Pop M, Ramirez JL, Rinta J, Robertson L, Salzberg SL, Sanchez DO, Seyler A, Sharma R, Shetty J, Simpson AJ, Sisk E, Tammi MT, Tarleton R, Teixeira S, Van Aken S, Vogt C, Ward PN, Wickstead B, Wortman J, White O, Fraser CM, Stuart KD, Andersson B (2005) Science 309 : 409-15Science 309 : 409-15
