Pharmacokinetics of dipyroxime was studied following intravenous injection to noninbred albino male rats. Dipyroxime is a cholinesterase reactivating drug now widely used as an antidote in poisonings caused by organophosphorus pesticides. Dipyroxime pharmacokinetics analysis made it possible to propose a formula for approximation of the data on another animal species (dogs). The drug concentration in the dog blood plasma is in a good correlation with the predicted level.
        
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Elaeva NL, Kul'bitskii GN, Predtechenskii MB (1987) [Pharmacokinetics of dipyroxime in the body of rats and dogs]. [Russian] Farmakologiia i Toksikologiia50: 85-7