Paper Report for: Eriksson_1989_Biochem.Biophys.Res.Commun_159_878
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Title: Extracellularly applied ATP alters the calcium flux through dihydropyridine-sensitive channels in cultured chick myotubes Eriksson H, Heilbronn E Ref: Biochemical & Biophysical Research Communications, 159:878, 1989 : PubMed
Extracellularly applied ATP mediates a biphasic calcium signal in cultured chick myotubes. A rapid and transient increase in cytosolic calcium was independent of extracellular calcium while a second signal, slower in onset and decay, was absent without extracellular calcium. In depolarized myotubes, the cytosolic [Ca2+] was increased more than ten times above baseline level. Addition of ATP to the incubation medium immediately increased the rate of return of cytosolic Ca2+ levels to baseline. The ATP effect was half-maximal at about 10 microM ATP and was mimicked by ATP S. This ATP-sensitive calcium influx was also rapidly stopped by addition of dihydropyridines such as PN 200-110, suggesting that it is the voltage operated Ca2+-channel that was inactivated by ATP.
        
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Eriksson H, Heilbronn E (1989) Extracellularly applied ATP alters the calcium flux through dihydropyridine-sensitive channels in cultured chick myotubes Biochemical & Biophysical Research Communications159: 878-85
Eriksson H, Heilbronn E (1989) Biochemical & Biophysical Research Communications159: 878-85