Paper Report for: Finger_1989_Pflugers.Arch_414_437
Reference
Title: Quantal stores of excitatory transmitter in nerve-muscle synapses of crayfish evaluated from high-frequency asynchronous quantal release induced by veratridine or high concentrations of potassium Finger W, Martin C Ref: Pflugers Arch, 414:437, 1989 : PubMed
At single voltage-clamped opener muscle fibres of crayfish claw, 10-100 mumol/l veratridine increased within a few seconds the rate of asynchronous quantal release, n, of excitatory transmitter from n less than 1 quantum/s to n congruent to 10,000 quanta/s. Thereafter n declined exponentially either with a single, tau(2) congruent to 50 s, or with two time constants tau(1) congruent to 19 s, tau(2) congruent to 50 s. In total (t----infinity), about 0.3 million quanta were released by veratridine in a single short fibre of about 1 mm length. These values were estimated by means of the noise analysis technique and they agreed with equivalent parameters of release when 100 mmol/l K+ were used as release stimulus. Strong quantal release could be elicited only once in a single muscle by veratridine. Furthermore, the effect of veratridine on quantal release could be completely prevented by pretreatment with tetrodotoxin. In another nerve-muscle preparation of crayfish, the abdominal superficial extensor muscle, up to 3 million excitatory quanta could be released by veratridine in a single fibre. In the latter muscle veratridine-induced asynchronous quantal release was strongly dependent on the extracellular concentration of Ca2+ whereas in the claw opener dependence of quantal release on extracellular Ca2+ was negligible.
        
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Finger W, Martin C (1989) Quantal stores of excitatory transmitter in nerve-muscle synapses of crayfish evaluated from high-frequency asynchronous quantal release induced by veratridine or high concentrations of potassium Pflugers Arch414: 437-42
Finger W, Martin C (1989) Pflugers Arch414: 437-42