Paper Report for: Ford_2003_Biochem.Biophys.Res.Commun_308_23
Reference
Title: Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes Ford BD, Liu Y, Mann MA, Krauss R, Phillips K, Gan L, Fischbach GD Ref: Biochemical & Biophysical Research Communications, 308:23, 2003 : PubMed
The neuregulin-1 family of growth factors regulates nicotinic acetylcholine receptor synthesis in skeletal muscle, but its role in cardiac myogenesis remains unclear. Here, we investigate the involvement of neuregulins in the development of cardiac cholinergic responsiveness. Treatment of chick cardiac myocytes with neuregulin-1 inhibited mRNA expression of the M4 muscarinic receptor, but not the M2 receptor. In addition, mRNA levels of GIRK1 were reduced in myocytes by treatment with neuregulin-1. Activation of cholinergic receptors in cultured chick atrial myocytes by carbachol produced an outward potassium current (I(K(ACh))), which was attenuated by 24-48-h pre-treatment with neuregulin-1. These data suggest that neuregulins can regulate cardiac parasympathetic tone and may be involved in the pathogenesis of cardiac arrhythmias and heart failure.
        
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Ford BD, Liu Y, Mann MA, Krauss R, Phillips K, Gan L, Fischbach GD (2003) Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes Biochemical & Biophysical Research Communications308: 23-8
Ford BD, Liu Y, Mann MA, Krauss R, Phillips K, Gan L, Fischbach GD (2003) Biochemical & Biophysical Research Communications308: 23-8