Paper Report for: Freeman_1988_Ann.N.Y.Acad.Sci_515_191
Reference
Title: Dopamine, acetylcholine, and glutamate interactions in aging. Behavioral and neurochemical correlates Freeman GB, Gibson GE Ref: Annals of the New York Academy of Sciences, 515:191, 1988 : PubMed
Aging, hypoxia, and thiamin deficiency diminish motor performance. Similar alterations of ACh, DA, and glutamate metabolism accompany hypoxia, thiamin deficiency, and aging. Both aging and hypoxia reduce ACh release and stimulate DA and glutamate release. Presynaptic enhancement of DA and glutamate release may be important in the production of cell damage that may contribute, in part, to age-related deficits in motor as well as cognitive function. The decline in ACh release may be important in the production of the cognitive deficits. An understanding of the interactions of neurotransmitters in hypoxia and thiamin deficiency aids our understanding of normal aging and increases the possibility of developing better treatments for the multiple neurotransmitter deficiencies that accompany many metabolic, age-related, and chronic degenerative disorders.
        
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Freeman GB, Gibson GE (1988) Dopamine, acetylcholine, and glutamate interactions in aging. Behavioral and neurochemical correlates Annals of the New York Academy of Sciences515: 191-202
Freeman GB, Gibson GE (1988) Annals of the New York Academy of Sciences515: 191-202