Paper Report for: Friedman_1983_Pharmacol.Biochem.Behav_19_309
Reference
Title: Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning Friedman E, Lerer B, Kuster J Ref: Pharmacol Biochem Behav, 19:309, 1983 : PubMed
Bilateral kainic acid lesions of the ventral globus pallidus produced a significant and selective cortical decrease in choline acetyltransferase activity in the rat brain. When lesioned and control subjects were compared on performance of a step-through passive avoidance task, lesioned rats showed a marked retention deficit 24 hr after the initial training trial. This experimentally-induced memory deficit associated with a cortical cholinergic neuronal loss resembles the deficits in senile dementia of the Alzheimer type and may provide a useful animal model for studying the disease.
        
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Friedman E, Lerer B, Kuster J (1983) Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning Pharmacol Biochem Behav19: 309-12