Title: Effects of human antithymocyte globulin on acetylcholine synthesis, its release and choline acetyltransferase transcription in a human leukemic T-cell line Fujii T, Ushiyama N, Hosonuma K, Suenaga A, Kawashima K Ref: Journal of Neuroimmunology, 128:1, 2002 : PubMed
Lymphocytes possess an independent, nonneuronal cholinergic system. In the present study, we investigated the short- and long-term effects of antithymocyte globulin (ATG)-Fresenius (ATG-F), a human antithymocyte globulin that binds to CD2, CD7 and CD11a, on acetylcholine (ACh) synthesis and transcription of choline acetyltransferase (ChAT) in CCRF-CEM cells, a human leukemic T-cell line. In the short-term (6 h), ATG-F enhanced ACh release, likely through transient increases in intracellular Ca(2+) ([Ca(2+)](i)) mediated by CD7, which led to declines in intracellular ACh content. By 48 h, however, the ACh content had increased as compared to control due to up-regulation of ChAT expression mediated by CD11a.
        
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Fujii T, Ushiyama N, Hosonuma K, Suenaga A, Kawashima K (2002) Effects of human antithymocyte globulin on acetylcholine synthesis, its release and choline acetyltransferase transcription in a human leukemic T-cell line Journal of Neuroimmunology128: 1-8
Fujii T, Ushiyama N, Hosonuma K, Suenaga A, Kawashima K (2002) Journal of Neuroimmunology128: 1-8