Paper Report for: Garcia_2006_J.Mol.Neurosci_30_57
Reference
Title: A comparison between acetylcholine-like action potentials and square depolarizing pulses in triggering calcium entry and exocytosis in bovine chromaffin cells Garcia de Diego AM, Arnaiz JJ, Gandia L, Hernandez-Guijo JM, Garcia AG Ref: Journal of Molecular Neuroscience, 30:57, 2006 : PubMed
Depending on experimental conditions, cell model, and pattern and type of depolarizing stimuli, the relationship between calcium entry ([Ca2+]c) and the release of neurotransmitters and hormones varies from exponential (power of 3-4) to near linear (power of 1.5) or linear function. Here, we present a study using the more physiological stimulation pattern based on acetylcholine (ACh)-like action potentials, in voltage-clamped bovine chromaffin cells, with the perforated-patch configuration of the patch-clamp technique and 2 mM extracellular calcium. Trains of ACh-like action potentials or square depolarizing pulses of increasing length were applied, and calcium currents (ICa), total calcium entry (QCa), and exocytosis (DeltaCm) measured.
        
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Garcia de Diego AM, Arnaiz JJ, Gandia L, Hernandez-Guijo JM, Garcia AG (2006) A comparison between acetylcholine-like action potentials and square depolarizing pulses in triggering calcium entry and exocytosis in bovine chromaffin cells Journal of Molecular Neuroscience30: 57-8
Garcia de Diego AM, Arnaiz JJ, Gandia L, Hernandez-Guijo JM, Garcia AG (2006) Journal of Molecular Neuroscience30: 57-8