Two novel ent-aromadendrane derivatives, plagiochianin A (1), possessing an unprecedented 2,3:6,7-di- seco-6,8-cyclo-aromadendrane carbon scaffold conjugated with three cyclic acetals, and plagiochianin B (2), an exceptional pyridine type aromadendrane alkaloid, were isolated from the Chinese liverwort Plagiochila duthiana. Their structures were established by comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction and electronic circular dichroism calculations. A plausible biogenetic pathway of these two compounds is presented, and their acetylcholinesterase inhibitory activities are preliminarily tested using TLC-bioautographic assays.
        
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Han JJ, Zhang JZ, Zhu RX, Li Y, Qiao YN, Gao Y, Jin XY, Chen W, Zhou JC, Lou HX (2018) Plagiochianins A and B, Two ent-2,3- seco-Aromadendrane Derivatives from the Liverwort Plagiochila duthiana Org Lett20: 6550-6553
Han JJ, Zhang JZ, Zhu RX, Li Y, Qiao YN, Gao Y, Jin XY, Chen W, Zhou JC, Lou HX (2018) Org Lett20: 6550-6553