Paper Report for: Hartzell_1992_Trends.Pharmacol.Sci_13_380
Reference
Title: Direct regulation of cardiac Ca2+ channels by G proteins: neither proven nor necessary? Hartzell HC, Fischmeister R Ref: Trends in Pharmacological Sciences, 13:380, 1992 : PubMed
The cardiac L-type Ca2+ channel has served as a model for ion channel regulation for over a decade. The Ca2+ current is increased by beta-adrenoceptor stimulation and this effect is inhibited by muscarinic acetylcholine receptor stimulation. It is well established that beta-adrenoceptor stimulation increases this current largely by cAMP-dependent phosphorylation but recently data have been presented that suggest that this channel may also be regulated directly by G proteins. This review by Criss Hartzell and Rodolphe Fischmeister evaluates evidence for this second regulatory pathway and concludes that, although G proteins affect cardiac Ca2+ channels in bilayers and excised patches, there is little evidence that this pathway is physiologically significant.
        
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Hartzell HC, Fischmeister R (1992) Direct regulation of cardiac Ca2+ channels by G proteins: neither proven nor necessary? Trends in Pharmacological Sciences13: 380-5
Hartzell HC, Fischmeister R (1992) Trends in Pharmacological Sciences13: 380-5