Paper Report for: Heo_2004_Dement.Geriatr.Cogn.Disord_17_151
Reference
Title: Naringenin from Citrus junos has an inhibitory effect on acetylcholinesterase and a mitigating effect on amnesia Heo HJ, Kim MJ, Lee JM, Choi SJ, Cho HY, Hong B, Kim HK, Kim E, Shin DH Ref: Dementia & Geriatric Cognitive Disorders, 17:151, 2004 : PubMed
This study was performed to identify safe and more effective acetylcholinesterase (AChE) inhibitors in the treatment of Alzheimer's disease. The total methanol extract of Citrus junos had a significant inhibitory effect on AChE in vitro. By sequential fractionation of C.junos, the active component was finally identified as naringenin. Naringenin inhibited AChE activity in a dose-dependent manner. In this study, we also evaluated the anti-amnesic activity of naringenin, a major flavanone constituent isolated from C. junos, in vivo using ICR mice with amnesia induced by scopolamine (1 mg/kg body weight). Naringenin, when administered to mice at 4.5 mg/kg body weight, significantly ameliorated scopolamine-induced amnesia as measured in both the passive avoidance and the Y-maze test. These results suggest that naringenin may be a useful chemopreventive agent against Alzheimer's disease.
        
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Heo HJ, Kim MJ, Lee JM, Choi SJ, Cho HY, Hong B, Kim HK, Kim E, Shin DH (2004) Naringenin from Citrus junos has an inhibitory effect on acetylcholinesterase and a mitigating effect on amnesia Dementia & Geriatric Cognitive Disorders17: 151-7
Heo HJ, Kim MJ, Lee JM, Choi SJ, Cho HY, Hong B, Kim HK, Kim E, Shin DH (2004) Dementia & Geriatric Cognitive Disorders17: 151-7