Paper Report for: Hroudova_2016_Eur.J.Med.Chem_121_774
Reference
Title: Progress in drug development for Alzheimer's disease: An overview in relation to mitochondrial energy metabolism Hroudova J, Singh N, Fisar Z, Ghosh KK Ref: Eur Journal of Medicinal Chemistry, 121:774, 2016 : PubMed
Current possibilities of Alzheimer's disease (AD) treatment are very limited and are based on administration of cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and/or N-methyl-d-aspartate receptor antagonist, memantine. Newly synthesized drugs affect multiple AD pathophysiological pathways and can act as inhibitors of cholinesterases (AChE, BuChE), inhibitors of monoamine oxidases (MAO-A, MAO-B), modulators of mitochondrial permeability transition pores, modulators of amyloid-beta binding alcohol dehydrogenase and antioxidants. Effects of clinically used as well as newly developed AD drugs were studied in relation to energy metabolism and mitochondrial functions, including oxidative phosphorylation, activities of enzymes of citric acid cycle or electron transfer system, mitochondrial membrane potential, calcium homeostasis, production of reactive oxygen species and MAO activity.
        
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Hroudova J, Singh N, Fisar Z, Ghosh KK (2016) Progress in drug development for Alzheimer's disease: An overview in relation to mitochondrial energy metabolism Eur Journal of Medicinal Chemistry121: 774-84
Hroudova J, Singh N, Fisar Z, Ghosh KK (2016) Eur Journal of Medicinal Chemistry121: 774-84