Paper Report for: Inestrosa_1994_J.Neurol.Sci_122_1
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Title: Blood markers in Alzheimer disease: subnormal acetylcholinesterase and butyrylcholinesterase in lymphocytes and erythrocytes Inestrosa NC, Alarcon R, Arriagada J, Donoso A, Alvarez J, Campos EO Ref: Journal of the Neurological Sciences, 122:1, 1994 : PubMed
In patients with the clinical diagnosis of Alzheimer disease (AD), we searched for systemic changes in components of the blood as a diagnostic tool. The acetylcholine-related enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BCHE) were measured in plasma, erythrocytes, platelets and lymphocytes. Results did not show a general effect; notwithstanding, specific cell types presented alterations either in AChE or BCHE but not in both enzymatic activities. In AD patients, AChE of lymphocytes was reduced by 60% compared with the age-matched controls. However, when patients were divided, the sporadic but not the familial subgroup exhibited a significant reduction. In erythrocytes the BCHE activity was reduced by 45% in sporadic AD. The molecular forms of the lymphocyte AChE were characterized by velocity sedimentation. Both globular forms were subnormal, more so the tetrameric G4 AChE form than the G2 form.
        
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Inestrosa NC, Alarcon R, Arriagada J, Donoso A, Alvarez J, Campos EO (1994) Blood markers in Alzheimer disease: subnormal acetylcholinesterase and butyrylcholinesterase in lymphocytes and erythrocytes Journal of the Neurological Sciences122: 1-5
Inestrosa NC, Alarcon R, Arriagada J, Donoso A, Alvarez J, Campos EO (1994) Journal of the Neurological Sciences122: 1-5