Paper Report for: Ishihara_1993_Chem.Pharm.Bull.(Tokyo)_41_529
Reference
Title: Central cholinergic agents. IV. Synthesis and acetylcholinesterase inhibitory activities of omega-[N-ethyl-N-(phenylmethyl)amino]-1-phenyl-1-alkanones and their analogues with partial conformational restriction Ishihara Y, Miyamoto M, Nakayama T, Goto G Ref: Chem Pharm Bull (Tokyo), 41:529, 1993 : PubMed
Inhibitors of acetylcholinesterase (AChE) have been designed based on a working hypothesis of the enzyme's active site. These compounds were tested for their inhibitory activities on AChE and omega-[N-ethyl-N-(phenylmethyl)amino]-1-phenyl-1-alkanones (3) were found to be potent inhibitors. Various analogues of 3 were prepared to study the effect on AChE inhibition of partial restriction of conformation. Compounds with potent AChE inhibition were further evaluated in terms of central selectivity: the ratio of central action (ameliorating effect on scopolamine-induced memory impairment using a T-maze alternation task) to peripheral action.
        
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Ishihara Y, Miyamoto M, Nakayama T, Goto G (1993) Central cholinergic agents. IV. Synthesis and acetylcholinesterase inhibitory activities of omega-[N-ethyl-N-(phenylmethyl)amino]-1-phenyl-1-alkanones and their analogues with partial conformational restriction Chem Pharm Bull (Tokyo)41: 529-38
Ishihara Y, Miyamoto M, Nakayama T, Goto G (1993) Chem Pharm Bull (Tokyo)41: 529-38