Direct and regioselective acylation of arbutin with aromatic or aliphatic acid using a lipase obtained from Candida antarctica in an organic solvent was investigated. We achieved the enzymatic synthesis of feruloyl arbutin and lipoyl arbutin without the need of vinyl ferulate and vinyl lipoate as acyl donors, respectively.
        
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Ishihara K, Katsube Y, Kumazawa N, Kuratani M, Masuoka N, Nakajima N (2010) Enzymatic preparation of arbutin derivatives: lipase-catalyzed direct acylation without the need of vinyl ester as an acyl donor J Biosci Bioeng109: 554-6
Ishihara K, Katsube Y, Kumazawa N, Kuratani M, Masuoka N, Nakajima N (2010) J Biosci Bioeng109: 554-6