Paper Report for: Ishihata_1991_Eur.J.Pharmacol_200_199
Reference
Title: Influence of aging on the contractile response to endothelin of rat thoracic aorta Ishihata A, Katano Y, Morinobu S, Endoh M Ref: European Journal of Pharmacology, 200:199, 1991 : PubMed
Age-related changes in the contractile response to endothelin-1 and ACh were assessed in thoracic aortas isolated from 2-, 6- and 24-month-old male Fischer 344 rats. In aortic strips with an intact endothelium, the maximal contractile response to endothelin-1 decreased with development to maturity. Removal of the endothelium did not affect the contractile response to endothelin-1. Endothelin-1 did not elicit a relaxant response in phenylephrine-precontracted strips. The ACh-induced relaxation decreased in senescent rats. These results indicate that the contractile response of aortic smooth muscle to endothelin-1 decreases with age, and that the endothelial vasorelaxant factors do not contribute to this age-induced modulation.
        
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Ishihata A, Katano Y, Morinobu S, Endoh M (1991) Influence of aging on the contractile response to endothelin of rat thoracic aorta European Journal of Pharmacology200: 199-201
Ishihata A, Katano Y, Morinobu S, Endoh M (1991) European Journal of Pharmacology200: 199-201