Changes in anergia/inhibition, mood, and pulse rate induced by intravenous physostigmine were significantly less pronounced in 26 patients with primary alcoholism than in 36 normal control subjects. These results suggest possible abnormalities in central cholinergic functioning in primary alcoholics.
        
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Janowsky DS, Risch SC, Irwin M, Schuckit MA (1989) Behavioral hyporeactivity to physostigmine in detoxified primary alcoholics Am J Psychiatry146: 538-9
Janowsky DS, Risch SC, Irwin M, Schuckit MA (1989) Am J Psychiatry146: 538-9