When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4]acetylcholine. The control of such choline uptake by the cytoplasmic acetylcholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.
        
Related information
Citations formats
Jenden DJ, Jope RS, Weiler MH (1976) Regulation of acetylcholine synthesis: does cytoplasmic acetylcholine control high affinity choline uptake? Science194: 635-7